Manuela Orjuela-Grimm is a molecular epidemiologist and pediatric oncologist whose research focuses on gene-nutrient/ environment interactions during pregnancy and early childhood and the development of later genetic and epigenetic changes in childhood disease. She leads a multidisciplinary team examining folate pathway metabolism and risk for retinoblastoma in collaboration with investigators in Mexico, and Canada, including the Hospital Infantil de Mexico, the Hospital de Pediatria (IMSS), the Instituto Nacional de Salud Publica (INSP), the Jean Mayer USDA at Tufts, and the University of Toronto. In collaboration with INSP researchers, Dr Orjuela is involved in multiple studies assessing dietary intake in Mexico and in recent Mexican immigrants. She is a member of the Leukemia & Lymphoma team in Pediatric Oncology. Interests: gene-nutrient interactions; one carbon donor metabolism; methylation; nutrient and environmental exposures during early life and later genetic and epigenetic effects; dietary assessment in Mexico and in US Latino populations; effects of acculturation and early life migration on nutrient/ environmental exposures in US Latinos.